As the Cannabis market grows for both medical and recreational use, so does the requirement for standardized quality control within the industry. In terms of Cannabis quality control there are lots of facts to consider, from moisture content to pesticide use.
Moisture Content – Cannabis flower moisture content needs to be tested and controlled to: minimize the chance of mold formation; control microbiological levels; ensure proper drying, curing and storage conditions; and support product life expectancy. Some manufacturing processes for cannabis quality assurance plan also need a certain water content inside the starting material.
Terpenoids and Cannabinoids Analysis
The amount of terpenoids and cannabinoids within the starting material determines the best choice industrial processing method and which final cannabis product will likely be manufactured. This analysis is normally performed using LC-MS (Liquid Chromatography Mass Spectrometry) or GC (Gas Chromatography). LC-MS and GC need a flow of inert gas including hydrogen or nitrogen, each of which can easily be supplied via a gas generator. Uncover more concerning the Peak Scientific range of gas generators for GC & LC-MS here.
Pesticides and Herbicides – As with other agricultural crops and products meant for human consumption, Cannabis plants ought to be tested for herbicides and pesticides. Detecting pesticides and herbicides can be difficult because of the complexity of cannabis material. GCMS (Gas Chromatography Mass Spectrometry) is normally used for this specific purpose.
Microbiological Screening – Medical Cannabis is frequently employed for HIV and cancer patients where the patient’s immunity mechanism has become compromised. Therefore, high microbial levels or pathogenic micro-organisms may be life-threatening. It is important then that several Mycotoxins and fungus types needs to be detected as part of cannabis quality control and release specifications.
Residual Solvents – Where solvents happen to be used included in Cannabis product processing, solvent residuals in the final products ought to be tested to ensure that they satisfy the accepted criteria. The FDA has published zvqtob criteria for residual solvents in APIs for pharmaceutical use.
Heavy Metals – Like various other plants, Cannabis draws metals from the earth. It really is therfore necessary to test for Mercury, Lead, Arsen and Cadmium.
Cannabinoid Concentration – Concentration ranges for cannabinoids including THC,THCa, CBD, CBDa, CBN, CBC, CBG should match the ranges specified on the product label, based upon product usage purpose, patient’s medical condition, age etc. Cannabinoid concentrations can be tested using LC-MS (Liquid Chromatography Mass Spectrometry) and HPLC (High Performance Liquid Chromatography) . You can find a variety of Peak Scientific nitrogen gas generators designed especially for LC-MS, available here.
Terpene Concentration – Terpenes increase cannabinoids’ therapeutic effects and are recognized to have their own own health advantages, additionally they bring about Cannabis taste and aroma. They can be detected using GC.
Taking the above under consideration, it is actually clear that there exists a necessity for standarized procedures for every step of the Cannabis analysis and testing process in order to guarantee safe use. The safest method to supply cannabis testing laboratories with gas for their LC-MS and GC is via gas generators, which do not present the health and safety risks related to gas cylinders.